STOP! You Don't Have To Live With Crepey Saggy Skin Any Longer!

It doesn’t matter if you’re 22 or 72.
You can restore your anti-aging system with this…

REPAIR YOUR SKIN’S 
ANTI-AGING SYSTEM WITH THIS 
TWO-MINUTE RITUAL

Your Body Already Has All The Tools
It Needs To Heal Your Skin From The Inside out.

Yep! All You Have To Do Is Learn To Activate It.

Keep Reading, We're About To Tell You How.
No Secrets. It's Too Simple.

What they’ve told you about aging is FALSE. 

You don’t just HAVE to start looking bad when you begin to get older. 

I bet you didn’t know...if you provide the right kind of nutrition to your anti-aging system, you’ll have people thinking you’re 10, 15, or even 20 years younger than you actually are! 

(This is a “secret” older women DESERVE to know! Because society tells us that getting older is a flat-out nightmare.)

And it can be - if you don’t know that you have a whole SYSTEM dedicated to keeping you looking young and healthy for as long as possible. 

No one ever talks about this, but it’s 100% true.
And right now, while you’re reading this, your internal “anti-aging system” is probably broken.

I know mine was...

But don’t worry. 
You can fix it. And once you do, how you look will be the least of your concerns.

I Was Ashamed Of My Skin!

The older I got, the more I felt like I was becoming a brand new person. Do you know what I mean? 

I needed reality to match what I was experiencing in my heart…

I felt more than just unattractive. I felt UGLY.

I was so hard on myself.

And you probably know exactly how I felt. 



I’d smile and see every line around my mouth. This made me not smile so big…which eventually had people thinking I was sad when I was really just trying to hide the wrinkles.



New hairstyles didn’t matter. I tried so many new hairstyles in an effort to take attention away from my face - and while a wonderful hairstyle is great, you still always end up thinking about the way you appear to others. My thoughts were CONSTANT. I felt ugly and unlovable. Have you ever felt that way too?




Makeup didn’t help. I mean, I did look a bit better with makeup, but makeup can’t fill in fine lines, creases, dimples - or give you a new face.



Even if I did get a compliment, I would just think they were being nice. . If someone called me beautiful, I absolutely didn’t believe it!

After trying as many pills, potions, and serums as I could…

…I was blown away to discover that I already have an anti-aging system inside my body. 

We all do.

My problem was that I had not been taking care of it very well or giving it the nutrition it needs. 

Well, that’s why I am here right now.

My name is Lynette…
…and I’m a lot like you

I meet women my age all the time, and they ask me how I look the way I do at the age of 65.

I mean seriously. Look at me. I am almost 70 years old, and people mistake me for someone in their 50s all the time.

Sometimes, even older men come and ask me what I’m doing to look so young

… and that’s is strange, because our society tells men they get better as they age. 

That’s just not true with women is it? So it’s nice for a man to come and ask me how I look so young when I’m almost 70 years old. 

See…women get called all kinds of disappointing names that don’t line up with our reality.

And the terms go on and on. You know what I mean....



Men get called “Silver Fox” and all sorts of other complimentary terms. I specifically remember a few years ago when an older gentleman who dressed well went viral.

Young women were asking whose grandfather that was like they wanted to meet him. 

To add insult to injury, modeling agencies started coming after him, and to this day he earns a living being an older, “beautiful” Sr. Citizen. 

This kind of thing happens to men all the time.

But as women age, it’s harder to see the things that make us so valuable and beautiful.

I don’t know about you, but the older I got…

  • The more confident I got. I knew what I knew about life and womanhood…and nothing could shake that.
  • I knew I was wiser than I was in my 20’s and 30’s. You couldn’t PAY me to go back to those years,. Most importantly…
  • The better life got! In fact, life continues to improve as I age. And THAT is the truth - not the marketing message they keep forcing on us.

ALL I WANT IS FOR MY FACE AND MY SKIN TO TELL THE REAL STORY OF WHO I AM AS A WOMAN, NOW.

Because this whole narrative that women who are older have miserable lives is a complete lie…and I’m sick of it! 🤦‍♀️

At this point, all I want to do is empower other women like me. So here’s the deal.

I’m just going to make it plain.

You need something that will help your skin do what it already wants to do, naturally.

And I don’t need to try any crazy sales tactics on you. 

I’m just going to give you the facts, and then leave you to make a decision for yourself. 

Because here’s what you need to know:

AGING IS NORMAL. AGING TOO QUICKLY IS NOT. 


And If You Take Care Of Your Anti-Aging System,
You Can Slow Down (and often reverse!) 
The Aging Process!

Don’t believe me?

Well…you know your Respiratory System?? The one that allows you to breathe and keeps your lungs healthy and working properly?

Just as there are things that you can do that are good for your lungs to keep them working well and you breathing easily…

…there are things you can do for your anti-aging system too. You can learn how to keep it healthy so you always look your age or younger!

(I bet you didn’t know that.)

Well…that’s what I want to talk to you about, today.

Your Anti-Aging System Controls The Way You Look!

And as long as you give it what it needs, you will NEVER look any older
than your actual age. And you’ll probably look younger than that.

You will know from the moment your feet hit the floor in the morning
that you’re showing up the absolute best you can each day.

In fact…you’ll probably start to catch people staring at you while
you’re speaking. They will be scrambling to figure out what
you’re doing to look younger.

No more extra dry CREPEY, LOOSE, SAGGY SKIN

People will be AMAZED.

In fact…this still happens to me to this day.

Everyone wants to know what I am doing. 

Well…all I’m doing is using a special cream every day…a cream that provides the right kind of nutrition to my anti-aging system.

(And just in case you think a cream isn’t that big of a deal…anything you put on your skin ends up in your bloodstream…which means your entire body will benefit if you start doing what I’m doing.)

I AM LIVING PROOF THAT 
WOMEN CAN BLOSSOM AT ANY AGE.

It doesn’t matter if you’re 22 or 72…there’s no such thing as “lucky genes.” 

The women who seem lucky are either nourishing their anti-aging system on purpose, or they are doing it accidentally as a normal part of their daily routine. 

But still…most of us think it’s all in the genes. 

We think some women are just “lucky.” 

I need to hammer this home. 

They are not lucky. There’s actually no such thing. 

If you are looking older than your age, it’s because your anti-aging system has begun to fall apart.

It’s not being properly nourished. And THAT is when we start to look older.

What Causes Crepey, Saggy Skin?

Just like any other problem, to fix it we must first understand what caused it.

Aged skin is caused by:

1. UVA/UVB Sun Damage
2. Slowed collagen production as a result of aging
3. Smoking & pollution
4. Skin dryness
5. Stress - yes, stress can cause you to age faster!
6. Rapid weight loss

Sun exposure is the number one and most common cause as it also contributes to dryness. This doesn't mean you sunbathe too much, just walking around in the world exposes you to the sun's ultraviolet light.

Over time, exposure to the sun breaks down elastin, the fibers in your skin that allow it to stretch and return to its normal position.

The main cause of skin aging is aged mitochondria, the energy powerhouse of the cell. ALL YOU HAVE TO DO IS REACTIVATE THEM!

When the mitochondria are old and tired from excessive oxidative stress, your skin cells won’t have the energy to repair themselves. They’re less able to hold moisture and the collagen starts to come apart, causing the skin to sag and become crepey.

The ONLY Way To Treat Your Mitochondria Is With LIPOSOMES - (Topical Creams Only Hit The Surface)

Liposomes are tiny bubbles that encapsulate the anti-aging ingredients and deliver them to the skin cells. Due to their low molecular weight they are able to penetrate the skin barrier and enter your cellular structure to affect change from the inside out!

So What Ingredients Do
We Need The Liposomes
To Deliver To Our Cells?

So let’s talk about this one, first since it’s an ingredient most of us are already familiar with, anyway.

(Retinol is just Vitamin A, by the way. I don’t know why they don’t just call it that.)

Anyway…you’ve probably heard of it. You may not know why it’s so popular, though.

After all, it’s the best-selling skincare product on both Amazon and Sephora. Anti-aging enthusiasts LOVE Retinol.

Basically…the reason for all the love is that Retinol forces your skin to regenerate faster than usual.

It’s very restorative and works best while you are sleeping. 

In fact, while you’re resting at night, Retinol pushes new, healthier skin to the forefront so that youthfulness is the first thing people see when they look at you.

In my personal opinion, everyone should use retinol before they go to bed at night.

“Retinol sinks into your skin and speeds up cell turnover, causing your body to churn out fresher, smoother skin again,” says dermatologist Dr. Mona Gohara, associate clinical professor at Yale University Medical School.

“It essentially tricks your body into thinking it’s younger than it is, effectively creating a real-life Benjamin Button scenario.”

Did you know there are at least 17,426 clinical studies showing that Retinol reduces fine lines, wrinkles, sagging skin, and more?!?

The Journal of The American Academy of Dermatology recently claimed:

“Retinol is hands down the industry’s gold standard ingredient. It has the power to help accelerate skin renewal and reduce the appearance of wrinkles, fine lines and age spots for firmer, smoother and more evenly-toned skin.”

The Next Ingredient Is The Strongest
ANTIOXIDANT On Planet Earth!

Why do we need antioxidants? Inflammation at the cellular level creates FREE RADICALS
that accelerate aging, they prevent skin cells from regenerating

Idebenone

Idebenone is an antioxidant and helps neutralize certain types of free radicals, which helps reduce blood flow as it protects cells from free radical damage.
After six weeks' use of the 1.0% idebenone formula, a 26% reduction in skin roughness/dryness was observed, a 37% increase in skin hydration, a 29% reduction in fine lines/wrinkles, and a 33% improvement in overall global assessment of photodamaged skin. For the 0.5% idebenone formulation, a 23% reduction in skin roughness/dryness was observed, a 37% increase in skin hydration, a 27% reduction in fine lines/wrinkles, and a 30% improvement in overall global assessment of photodamaged skin. (1)

Hyaluronic Acid

Hyaluronic Acid Molecules Hold 1,000 Times Their Weight In Water

Hydration is CRITICAL to the human body, that's no secret.
Your cells MUST be properly hydrated in order to heal and regenerate effectively

I WANTED AN ANTI-AGING FORMULA 
THAT COULD TRULY DO IT ALL…SO I TRIED THEM ALL!

Best Neck & Skin Firming Creams 2021

I got these results from only 1 month of using my top choice...read more and learn WHY it worked!

What You Need Is A Liposomal Cream

A liposome is a tiny bubble (vesicle), made out of the same material as a cell membrane. Liposomes can be filled with nutrients, and used to deliver them through the skin's barrier due to their low molecular weight. Membranes are usually made of phospholipids, which are molecules that have a head group and a tail group.

A liposomal cream BONDS TO EVERY LAYER OF SKIN ON ITS WAY DOWN. So more of the anti aging ingredients make it into your cells than a standard cream. 

Topical creams are just that (they only treat the top) - the problem is aging skin cells need to be treated directly. That means your cream MUST have a low molecular weight and be encapsulated into a LIPOSOME.
What causes crepey, loose skin skin? (READ THIS, IT'S IMPORTANT TO UNDERSTAND)

Sun damage is the most common cause of crepey skin, but it certainly isn't the only cause. Crepey skin can also result from aging, a lack of moisture, excessive weight loss, or any combination of these.

The ultraviolet light in the sun’s rays break down collagen and elastin in skin that help it stay tight and wrinkle-free. Once these fibers break down, the skin can loosen, thin, and wrinkle.

Age is also a factor. You produce less collagen and elastin — the fibers that help your skin look supple and smooth — the older you get. Pollution, stress, and smoking cigarettes all take a toll on skin over your lifetime and can contribute to visible signs of aging.

As you age, your skin produces less oil than it did when you were younger. These oils create an important lipid barrier that protects your skin and helps seal in moisture. Hormonal changes can also lead to drier skin and less natural oil production. 

What To Look Out For, In An Effective Crepey Skin Repair Cream?

  • It should contain these active ingredients: Idebenone, Hyaluronic Acid, Retinol, Collagen and natural amino acids.
  • It should be liposomal and absorb into your cells directly, topical creams are a waste of money.***
  • It should contain Hyaluronic Acid to deliver a moisture boost and plump the tired skin
  • ​It MUST have Idebenone - it's the most powerful antioxidant known to science.
  • ​It MUST have Retinol - This is the ultimate in skin firming ingredients, very effective.

Idebenone Is The Real Key To Anti-Aging

Idebenone is considered to be one of the top-rated anti-aging drugs due to its ability to rejuvenate and preserve dying tissue mitochondria. Idebenone is so highly respected that it is used as an organ preservative when transporting live organs for organ transplant procedures (2 scientific references below). It works because it has two functions. 

First, it scavenges the body for free radicals (caused by old age, smoking, pollution, alcohol, sun damage . . . ). Only when delivered via liposome (3 scientific references below) can idebenone regulate and normalizes energy production in mitochondria of the cell. Topical creams are useless. 

Once expressed into the cell via liposome the idebenone can diminish the appearance of fine lines and wrinkles as it reverses UVA/UVB photodamage to skin cells (scientific reference below) It found a 26% reduction in skin roughness/dryness was observed, a 37% increase in skin hydration, a 29% reduction in fine lines/wrinkles, and a 33% improvement in overall global assessment of photodamaged skin. 

In recent studies, Idebenone was shown EXTREMELY effective in treating sun damaged skin.

Our Choices

I've extensively researched dozens of products and will be providing a brief review of the top 5 products. We're going to compare several aspects of each product, including success rates (short and long term), quality of ingredients, affordability, as well as customer rankings, and reviews. Below you will find the top 5 products of 2020.
Our Sources:
Author Lynette Fredrics

After my years of working in a fitness center, I constantly hear people talking about different products they use to help them look and feel their best, along with other supplements they use to help improve heart health and fuel their body's weight loss.

Now I work as a beauty specialist, alongside my team of experts. We conduct extensive research for non-profit beauty organizations. I would love to share our findings, which were acquired by personally testing each product, carefully examining their results, and side effects, if any. We've ranked them based on these findings along with several other factors mentioned on this page.

#1. Crepe Repair Neck & Skin Firming Cream - Liposomal Collagen Restoration

Pros

  • ​Contains Idebenone
  • ​Contains Retinol
  • ​Hyaluronic Acid
  • ​Contains Amino Acids
  • ​All Natural Ingredients
  • ​No Unnecessary Fillers
  • ​30-day Money-back Guarantee
  • ​No Surprise Automatic Rebilling
  • ​US Customer Support
  • ​Better Value Than Our Second Pick

Cons

  • ​Shipping took an extra day

The Bottom Line

Unlike other lower-quality neck firming creams we reviewed, this cream TREATS THE SKIN MITOCHONDRIA DIRECTLY, WHICH IS THE ACTUAL CAUSE OF CREPEY LOOSE SKIN. THIS CREAM WILL FIRM YOUR SKIN FAST.

A deeper look at the active ingredients contained in it demonstrates that Idebeone is an ingredient frequently included in products designed to stimulate collagen production and synthesis, thus improving the skin’s tensile strength and its ability to resist stretching and sagging. 

This cream checks all the boxes for us, its liposomal, it has Idebenone & it also has Hyaluronic Acid & Retinol which is well known for skin firming and treatment of fine lines.

If you're looking for a crepey skin treatment thats affordable and you can do at home, this is the cream for you. Read their reviews...they're nothing short of amazing.

This cream is also less expensive than the competition because you only need a SINGLE CREAM vs an entire system to be effective.

This cream also lasts longer because you only need a thin layer due to it being Liposomal. You also only need to use it 1x daily.

As a reader of my site you can save up to 40% on your first order by clicking the button below!

We also appreciate the fact that this Neck Firming & Crepe Correcting Cream is made with non-GMO ingredients, is paraben free, and is formulated for all skin types.

***I USED THE CREAM MYSELF AND IT MADE A HUGE DIFFERENCE

You can get THIS AMZING CREAM for as little as 1.74 cents per day… LESS THAN A CUP OF COFFEE

Oh, and did I mention you can try it RISK FREE FOR 30 DAYS!

#2 - Crepe Erase Intensive Body Repair Treatment with TruFirm Complex, Original Citrus - $79

Pros

  • Popular Brand

Cons

  • ​More expensive
  • ​No Idebenone
  • ​No Hyaluronic Acid
  • No Liposomal

A Real Amazon Review...

I don't know why I was so foolish to order this item from a TV doc with an orange spray tan. I put my personal feelings aside and decided to try the product. First of all, the product is packaged so incredibly cheaply. There is no box, there is no pamphlet, there is no clinical research given (i.e. "After 6 weeks 55% of patients experienced ___ change in the appearance of their skin. After 12 weeks 90% of patients experienced____ change in the appearance of their skin"). 

There are no instructions other than a quick three lines on the container itself. The product arrived on a piece of cardboard with plastic wrap securing it in place... that's the extent of the presentation for something that costs almost $90. The product feels and smells like Ponds cold cream, the stuff our mothers and grandmothers bought at the drug store for years. Perhaps I'll buy some Ponds for $5 and see if that works because this is a scam being promoted by a charlatan. I assume full responsibility for being so stupid. Don't be stupid and don't waste your time or money on Crepe Erase... err, Crap Erase.

At $79 for a single jar, its significantly more expensive than our top pick

They also do not offer a money back guarantee like our top pick, I guess they're no so confident in their product. This product is also more expensive than our top pick.

3. Strivectin®

Pros

  • ​Nice package

Cons

  • ​More expensive that top pick
  • ​No Idebenone
  • ​No Hyaluronic Acid
  • ​Very Expensive

The Bottom Line

Strivectin® TL Advanced Tightening Neck Cream Plus contains a large number of ingredients, including peptides, ceramides, hyaluronic acid, and three ingredient complexes that are unique to Strivectin® products. According to the manufacturer’s website, Strivectin®’s neck cream was formulated to provide an instantaneous tightening effect as well as a noticeable improvement in skin’s appearance overtime.

Our research indicates that Strivectin®’s neck cream also contains Nia-114, which appears to be their own blend of vitamin B, which is added to many of their skin care products and used to improve hydration of the skin. The hyaluronic acid and ceramides in the product also boost water retention and improve skin hydration.

Several customers provided feedback that led us to believe that the product might not be the best for everyone, including information that led us to believe that this neck firming cream might be a better choice for those with dry skin – not those with normal or excessive oily skin.

We also found the product to contain over 40 different ingredients, including things like Sorbitan Laurate, a food additive, undefined fragrances and perfumes, and Ethylene/Acrylic Acid Copolymer – for which we found research indicating potential toxicity, depending on the concentration.

Considering the vast number of ingredients, and limited research supporting effectiveness available for some, our research team felt other neck firming options included in this review were a better option, both for quality and value.

Our reviewers found the company’s website contained a lot of information about the product; however, when reviewing the product itself, although they found it to have a smooth, non-greasy texture, it is a bit more expensive then other creams in this review, especially when considering the mixed reviews provided by customers.

Available for 1.7 fl oz jar for $95, PRODUCT works out to be $56 per fluid ounce and is second highest ranked product in this review.

* Results are based on our system and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.


1. studies 
QSA 10 (idebenone) supplementation of organ preservation solutions prevents oxygen radical-mediated injury of hepatic microsomes E Wieland 1, E Schütz, V W Armstrong, B Ringe, M Oellerich PMID: 7879165

Similar articles Idebenone protects hepatic microsomes against oxygen radical-mediated damage in organ preservation solutions Wieland E, Schütz E, Armstrong VW, Küthe F, Heller C, Oellerich M. Transplantation. 1995 Sep 15;60(5):444-51. doi: 10.1097/00007890-199509000-00007. PMID: 7676491

2. Second scientific reference Idebenone: Novel Strategies to Improve Its Systemic and Local Efficacy

Lucia Montenegro 1, Rita Turnaturi 2, Carmela Parenti 3, Lorella Pasquinucci 4
Affiliations expand
PMID: 29401722 PMCID: PMC5853719 DOI: 10.3390/nano8020087
Free PMC article
Abstract

The key role of antioxidants in treating and preventing many systemic and topical diseases is well recognized. One of the most potent antioxidants available for pharmaceutical and cosmetic use is Idebenone (IDE), a synthetic analogue of Coenzyme Q10. Unfortunately, IDE's unfavorable physicochemical properties such as poor water solubility and high lipophilicity impair its bioavailability after oral and topical administration and prevent its parenteral use. In recent decades, many strategies have been proposed to improve IDE effectiveness in the treatment of neurodegenerative diseases and skin disorders. After a brief description of IDE potential therapeutic applications and its pharmacokinetic and pharmacodynamic profile, this review will focus on the different approaches investigated to overcome IDE drawbacks, such as IDE incorporation into different types of delivery systems (liposomes, cyclodextrins, microemulsions, self-micro-emulsifying drug delivery systems, lipid-based nanoparticles, polymeric nanoparticles) and IDE chemical modification. The results of these studies will be illustrated with emphasis on the most innovative strategies and their future perspectives.



Tolerability and improved protective action of idebenone-loaded pegylated liposomes on ethanol-induced injury in primary cortical astrocytes

Donatella Paolino 1, Michelangelo Iannone, Venera Cardile, Marcella Renis, Giovanni Puglisi, Domenicantonio Rotiroti, Massimo Fresta
Affiliations expand
PMID: 15176069 DOI: 10.1002/jps.20088
Abstract

The potential therapeutic advantages of the encapsulation of idebenone within pegylated liposomes were investigated in vitro on primary cortical astrocytes of rats. In particular, both the concentration-dependent effects and the therapeutic effectiveness toward excitotoxic injury, elicited by chronic treatment with ethanol (100 microM) for 12 days, were evaluated. The following parameters were taken into consideration to assay free or liposomally entrapped idebenone: lactic dehydrogenase release, respiratory capacity measured by tetrazolium salt conversion, glutamine synthetase, and the levels of constitutive and inducible 70-kDa heat shock proteins. To evaluate the effects on astrocytes, three different drug concentrations were used (0.5 microM, 5 microM, and 50 microM). At the highest concentration used (50 microM), a toxic effect of the free and liposomally entrapped drug was observed. Toxic effects seem to be due to a cellular membrane perturbation, as demonstrated by (45)Ca(2+) permeation. The therapeutic effect of free or liposomally entrapped idebenone on ethanol-induced injury of primary cortical astrocytes was evaluated as a function of the drug concentration. The drug liposome formulation was much more effective than the free drug in counteracting the ethanol-induced damage in astrocytes, i.e., 10-times-lower doses of liposomally entrapped idebenone are able to provide a greater protective action than the free drug. The improved action of idebenone-loaded liposomes is probably due to the greater drug bioavailability at the cellular level.

Copyright 2004 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 93:1815-1827, 2004

Differential Scanning Calorimetry Analyses of Idebenone-Loaded Solid Lipid Nanoparticles Interactions with a Model of Bio-Membrane: A Comparison with In Vitro Skin Permeation Data

Lucia Montenegro 1, Francesco Castelli 2, Maria Grazia Sarpietro 3
Affiliations expand
PMID: 30558360 PMCID: PMC6316718 DOI: 10.3390/ph11040138
Free PMC article
Abstract

Differential scanning calorimetry (DSC) has emerged as a helpful technique both to characterize drug delivery systems and to study their interactions with bio-membranes. In this work, we compared idebenone (IDE)-loaded solid lipid nanoparticle (SLN) interactions with bio-membranes assessed by DSC with previous in vitro skin penetration data to evaluate the feasibility of predicting IDE skin penetration using DSC analyses. In vitro interactions experiments were performed using multi-lamellar liposomes as a model of bio-membrane. Enthalpy changes (ΔH) and transition temperature (Tm) were assessed during nine repeated DSC scans to evaluate IDE-loaded SLN⁻bio-membrane interactions over time. Analyzing ΔH and Tm values for each scan, we observed that the difference of ΔH and Tm values between the first and the last scan seemed to be related to SLN ability to locate IDE in the epidermis and in the stratum corneum, respectively. Therefore, the results of this study suggest the possibility of qualitatively predicting in vitro IDE skin penetration from IDE-loaded SLN utilizing the calorimetric parameters obtained from interaction experiments between the carriers under investigation and a model of bio-membrane.



Clinical efficacy assessment in photodamaged skin of 0.5% and 1.0% idebenone

D H McDaniel 1, B A Neudecker, J C DiNardo, J A Lewis 2nd, H I Maibach
Affiliations expand
PMID: 17129261 DOI: 10.1111/j.1473-2165.2005.00305.x
Abstract

Idebenone is an antioxidant lower molecular weight analogue of coenzyme Q10. Previously, idebenone was shown to be a very effective antioxidant in its ability to protect against cell damage from oxidative stress in a variety of biochemical, cell biological, and in vivo methods, including its ability to suppress sunburn cell (SBC) formation in living skin. However, no clinical studies have been previously conducted to establish the efficacy of idebenone in a topical skincare formulation for the treatment of photodamaged skin. In this nonvehicle control study, 0.5% and 1.0% idebenone commercial formulations were evaluated in a clinical trial for topical safety and efficacy in photodamaged skin. Forty-one female subjects, aged 30-65, with moderate photodamaged skin were randomized to use a blind labelled (either 0.5% or 1.0% idebenone in otherwise identical lotion bases) skincare preparation twice daily for six weeks. Blinded expert grader assessments for skin roughness/dryness, fine lines/wrinkles, and global improvement in photodamage were performed at baseline, three weeks and six weeks. Electrical conductance readings for skin surface hydration and 35 mm digital photography were made at baseline after six weeks. Punch biopsies were taken from randomly selected subjects, baseline and after six weeks, and stained for certain antibodies (interleukin IL-6, interleukin IL-1b, matrixmetalloproteinase MMP-1, collagen I) using immunofluorescence microscopy. After six weeks' use of the 1.0% idebenone formula, a 26% reduction in skin roughness/dryness was observed, a 37% increase in skin hydration, a 29% reduction in fine lines/wrinkles, and a 33% improvement in overall global assessment of photodamaged skin. For the 0.5% idebenone formulation, a 23% reduction in skin roughness/dryness was observed, a 37% increase in skin hydration, a 27% reduction in fine lines/wrinkles, and a 30% improvement in overall global assessment of photodamaged skin. The immunofluorescence staining revealed a decrease in IL-1b, IL-6, and MMP-1 and an increase in collagen I for both concentrations.

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On our page you may find affiliate links for which we could be compensated by clicking on them. The information contained within this site is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, you are urged to consult with a health care provider. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any diseases or medical conditions. Results are based on the Best Beets Review Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.